Welcome to the Shair Lab!
R E S E A R C H
The Shair lab uses small molecules and cell biology as part of an integrated approach to study the mechanistic basis of human diseases, identify new druggable targets and develop therapeutics.
T E A M
Our research is highly interdisciplinary, with chemists and biologists working side-by-side. Chemists apply modern stereoselective synthesis to discover highly selective small molecules that target proteins involved in human disease. Biologists combine small molecules with genome-wide and proteome-wide studies, CRISPR-Cas9 genome editing and iPSCs and primary patient samples to investigate human disease.
P U B L I C A T I O N S
We invite you to explore our publications, including our recent study revealing a dependency of acute myeloid leukemia (AML) on CDK8/19 kinase activity. Using the small molecule CDK8/19 inhibitor cortistatin A, we discovered that AML cells depend on CDK8/19 activity to restrain transcription of cell identity genes.
© SHAIR LAB 2016
