Our research is highly interdisciplinary, with chemists and biologists working side-by-side. Chemists apply modern stereoselective synthesis to discover highly selective small molecules that target proteins involved in human disease. Biologists combine small molecules with genome-wide and proteome-wide studies, CRISPR-Cas9 genome editing and iPSCs and primary patient samples to investigate human disease.
We invite you to explore our publications, including our recent study revealing a dependency of acute myeloid leukemia (AML) on CDK8/19 kinase activity. Using the small molecule CDK8/19 inhibitor cortistatin A, we discovered that AML cells depend on CDK8/19 activity to restrain transcription of cell identity genes.